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02 Feb

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further performed genotyping for 67 mothers from the oxycodone group for 4 polymorphic genes involved in oxycodone metabolism and response (ie, CYP 2D6; CYP 3A5; µ opioid receptor; and ATP-binding cassette, subfamily B, member 1 [ABCB1]).It is recommended that mothers continue breastfeeding, provided the infant is monitored for potential adverse CNS effects.Compared with mothers of asymptomatic infants, mothers of symptomatic infants used, on average, 59% higher doses of codeine.Benzodiazepines (BZDs), antihistamines, and opioids are a few classes of sedating drugs commonly used by breastfeeding mothers.As a general rule, when the relative infant dose (the amount of a drug excreted into breast milk relative to the maternal dose) is less than 10%, it is considered compatible with breastfeeding.